Identification of the cytochrome P450 enzymes involved in the metabolism of domperidone

@article{Simard2004IdentificationOT,
  title={Identification of the cytochrome P450 enzymes involved in the metabolism of domperidone},
  author={Chantale Simard and Veronique Michaud and Brian Gibbs and Robert Mass{\'e} and {\'E}tienne Lessard and Jacques Turgeon},
  journal={Xenobiotica},
  year={2004},
  volume={34},
  pages={1013 - 1023}
}
1. The objective was to identify the major cytochrome P450 enzyme(s) involved in the metabolism of domperidone. 2. Experiments were performed using human liver microsomes (HLMs), recombinant human cytochrome P450 enzymes, cytochrome P450 chemical inhibitors and monoclonal antibodies directed against cytochrome P450 enzymes. 3. Four metabolites were identified from incubations performed with HLMs and excellent correlations were observed between the formation of domperidone hydroxylated… 
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