Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization.

@article{Akhavan2005IdentificationOT,
  title={Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization.},
  author={Armin Akhavan and Roxana Atanasiu and Tomohiro Noguchi and Wei Han and Natasha Holder and Alvin Shrier},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 13},
  pages={2803-12}
}
Mutations of a putative cyclic-nucleotide-binding domain (CNBD) can disrupt the function of the hyperpolarization-activated cyclic-nucleotide-gated channel (HCN2) and the human ether-a-go-go-related gene potassium channel (HERG). Loss of function caused by C-terminal truncation, which includes all or part of the CNBD in HCN and HERG, has been related to abnormal channel trafficking. Similar defects have been reported for several of the missense mutations of HERG associated with long QT syndrome… CONTINUE READING