Identification of the coupling between skeletal muscle store-operated Ca2+ entry and the inositol trisphosphate receptor.

@article{Launikonis2003IdentificationOT,
  title={Identification of the coupling between skeletal muscle store-operated Ca2+ entry and the inositol trisphosphate receptor.},
  author={Bradley S Launikonis and Melissa Barnes and D George Stephenson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 5},
  pages={2941-4}
}
Examination of store-operated Ca(2+) entry (SOC) in single, mechanically skinned skeletal muscle cells by confocal microscopy shows that the inositol 1,4,5-trisphosphate (IP(3)) receptor acts as a sarcoplasmic reticulum [Ca(2+)] sensor and mediates SOC by physical coupling without playing a key role in Ca(2+) release from internal stores, as is the case with various cell types in which SOC was investigated previously. The results have broad implications for understanding the mechanism of SOC… CONTINUE READING

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