Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18).

@article{Ueda1994IdentificationOT,
  title={Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18).},
  author={Tetsuo Ueda and Philippe Rieu and Jason Brayer and M. Amin Arnaout},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 22},
  pages={10680-4}
}
The divalent cation-dependent interaction of the beta 2 integrin CR3 (CD11b/CD18) with the major complement opsonic C3 fragment iC3b is an important component of the central role of CR3 in inflammation and immune clearance. In this investigation we have identified the iC3b binding site in CR3. A recombinant fragment representing the CR3 A-domain, a 200-amino acid region in the ectodomain of the CD11b subunit, bound to iC3b directly and in a divalent cation-dependent manner. The iC3b binding… CONTINUE READING

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