Identification of the catalytic subunit of acetohydroxyacid synthase in Haemophilus influenzae and its potent inhibitors.

@article{Choi2007IdentificationOT,
  title={Identification of the catalytic subunit of acetohydroxyacid synthase in Haemophilus influenzae and its potent inhibitors.},
  author={Kyoung-Jae Choi and Kyoung Mi Noh and Dong-Min Kim and Byung Hak Ha and Eunice Eunkyung Kim and M O Yoon},
  journal={Archives of biochemistry and biophysics},
  year={2007},
  volume={466 1},
  pages={24-30}
}
Acetohydroxyacid synthase (AHAS; EC 2.2.1.6) is a thiamin diphosphate- (ThDP)- and FAD-dependent enzyme that catalyzes the first common step in the biosynthetic pathway of the branched-amino acids (BCAAs) leucine, isoleucine, and valine. The gene from Haemophilus influenzae that encodes the AHAS catalytic subunit was cloned, overexpressed in Escherichia… CONTINUE READING