Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196

Abstract

A-500359s, produced by Streptomyces griseus SANK60196, are inhibitors of bacterial phospho-N-acetylmuramyl-pentapeptide translocase. They are composed of three distinct moieties: a 5′-carbamoyl uridine, an unsaturated hexuronic acid and an aminocaprolactam. Two contiguous cosmids covering a 65-kb region of DNA and encoding 38 open reading frames (ORFs… (More)
DOI: 10.1038/ja.2009.38

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@article{Funabashi2009IdentificationOT, title={Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196}, author={Masanori Funabashi and Koichi Nonaka and Chieko Yada and Masahiko Hosobuchi and Nobuhisa Masuda and Tomoyuki Shibata and Steven G. Van Lanen}, journal={The Journal of Antibiotics}, year={2009}, volume={62}, pages={325-332} }