Identification of the amino acid residues in the extracellular domain of rat P2X(7) receptor involved in functional inhibition by acidic pH.

@article{Liu2009IdentificationOT,
  title={Identification of the amino acid residues in the extracellular domain of rat P2X(7) receptor involved in functional inhibition by acidic pH.},
  author={Xuantong Liu and Wenfu Ma and Annmarie Surprenant and Li-he Jiang},
  journal={British journal of pharmacology},
  year={2009},
  volume={156 1},
  pages={
          135-42
        }
}
BACKGROUND AND PURPOSE P2X(7), receptors are potently inhibited by extracellular acidification. The underlying molecular basis remains unknown. This study aimed to examine the role of extracellular histidine, lysine, aspartic acid and glutamic acid residues in the functional inhibition of rat P2X(7) receptors by acidic pH. EXPERIMENTAL APPROACH We introduced point mutations into rat P2X(7) receptor by site-directed mutagenesis, expressed wild type (WT) and mutant receptors in human embryonic… CONTINUE READING

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