Identification of the alpha1L-adrenoceptor in rat cerebral cortex and possible relationship between alpha1L- and alpha1A-adrenoceptors.

@article{Morishima2008IdentificationOT,
  title={Identification of the alpha1L-adrenoceptor in rat cerebral cortex and possible relationship between alpha1L- and alpha1A-adrenoceptors.},
  author={Shigeru Morishima and Fumiko Suzuki and Hatsumi Yoshiki and Abu Syed Md Anisuzzaman and Zakia Sultana Sathi and Takashi Tanaka and Ikunobu Muramatsu},
  journal={British journal of pharmacology},
  year={2008},
  volume={153 7},
  pages={1485-94}
}
BACKGROUND AND PURPOSE In addition to alpha1A, alpha1B and alpha1D-adrenoceptors (ARs), putative alpha1L-ARs with a low affinity for prazosin have been proposed. The purpose of the present study was to identify the alpha1A-AR and clarify its pharmacological profile using a radioligand binding assay. EXPERIMENTAL APPROACH Binding experiments with [3H]-silodosin and [3H]-prazosin were performed in intact tissue segments and crude membrane preparations of rat cerebral cortex. Intact tissue… CONTINUE READING