Identification of the alpha IIb beta 3 integrin in murine tumor cells.

@article{Chen1992IdentificationOT,
  title={Identification of the alpha IIb beta 3 integrin in murine tumor cells.},
  author={Y Q Chen and Xiang Gao and J{\'o}zsef T{\'i}m{\'a}r and Dan Tang and Irma M. Grossi and Mohan Chelladurai and Thomas J. Kunicki and Suzanne E. G. Fligiel and John Eric Taylor and Kenneth V. Honn},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 24},
  pages={17314-20}
}
Previously, we have identified an alpha IIb beta 3-like integrin in tumor cells by using antibodies against platelet alpha IIb beta 3. However, alpha IIb beta 3 was considered to be expressed strictly in megakaryocyte lineage cells. In order to resolve this controversy, the alpha IIb beta 3-like integrin in murine B16 amelanotic melanoma (B16a) cells was characterized at DNA, RNA, and protein levels. The presence of alpha 5, alpha v, alpha IIb, beta 1, and beta 3 genes in B16a cells was… CONTINUE READING