Identification of the active metabolite of ticlopidine from rat in vitro metabolites.

@article{Yoneda2004IdentificationOT,
  title={Identification of the active metabolite of ticlopidine from rat in vitro metabolites.},
  author={Kenji Yoneda and Ryou Iwamura and Hiroko Kishi and Yoichi Mizukami and Kimiko Mogami and Sei Kobayashi},
  journal={British journal of pharmacology},
  year={2004},
  volume={142 3},
  pages={551-7}
}
1 Ticlopidine is a well-known anti-platelet agent, but is not active by itself in vitro. We identified a metabolite with anti-platelet activity, which was generated after incubation of 2-oxo-ticlopidine with phenobarbital-induced rat liver homogenate in vitro. 2 An active moiety (UR-4501) was isolated by high-performance liquid chromatography after large-scale preparation of metabolites. 3 The chemical structure of UR-4501 was determined by a combination of liquid chromatography mass/mass… CONTINUE READING

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