Identification of the activation-induced cytidine deaminase gene from zebrafish: an evolutionary analysis.

@article{Zhao2005IdentificationOT,
  title={Identification of the activation-induced cytidine deaminase gene from zebrafish: an evolutionary analysis.},
  author={Yaofeng Zhao and Qiang Pan-Hammarstr{\"o}m and Zhihui Zhao and Lennart Hammarstr{\"o}m},
  journal={Developmental and comparative immunology},
  year={2005},
  volume={29 1},
  pages={61-71}
}
In the present study, we report the identification of the activation-induced cytidine deaminase (AID) encoding gene in frog, dog and chimpanzee, where both somatic hypermutation and class switch recombination (CSR) occurs and in zebrafish and fugu, species lacking CSR. The cDNA sequence of the zebrafish AID reported here suggests both N and C ends of the previously predicted protein sequence are incorrect. A comparison of AID sequences among mammals, birds, amphibians and fish revealed… CONTINUE READING
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