Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.

@article{Liu2005IdentificationOT,
  title={Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.},
  author={J. Liu and A. Bang and C. Kintner and A. Orth and S. Chanda and S. Ding and P. Schultz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 6},
  pages={
          1927-32
        }
}
  • J. Liu, A. Bang, +4 authors P. Schultz
  • Published 2005
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
The Wnt signaling pathway acts ubiquitously in metazoans to control various aspects of embryonic development. Wnt ligands bind their receptors Frizzled and low-density lipoprotein receptor-related protein 5/6 and function through Disheveled (Dvl), Axin, adenomatous polyposis coli, glycogen synthase kinase 3beta, and casein kinase (CK) 1 to stabilize beta-catenin and induce lymphocyte enhancer-binding factor (LEF)/T cell factor (TCF)-dependent transcriptional activities. To identify previously… Expand
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