Identification of the Upward Movement of Human CSF In Vivo and its Relation to the Brain Venous System

@article{DrehaKulaczewski2017IdentificationOT,
  title={Identification of the Upward Movement of Human CSF In Vivo and its Relation to the Brain Venous System},
  author={Steffi Dreha-Kulaczewski and Arun A. Joseph and Klaus-Dietmar Merboldt and Hans Christoph Ludwig and Jutta G{\"a}rtner and Jens Frahm},
  journal={The Journal of Neuroscience},
  year={2017},
  volume={37},
  pages={2395 - 2402}
}
CSF flux is involved in the pathophysiology of neurodegenerative diseases and cognitive impairment after traumatic brain injury, all hallmarked by the accumulation of cellular metabolic waste. Its effective disposal via various CSF routes has been demonstrated in animal models. In contrast, the CSF dynamics in humans are still poorly understood. Using novel real-time MRI, forced inspiration has been identified recently as a main driving force of CSF flow in the human brain. Exploiting technical… 

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