Identification of the Streptococcus mutans LytST two-component regulon reveals its contribution to oxidative stress tolerance

@inproceedings{Ahn2012IdentificationOT,
  title={Identification of the Streptococcus mutans LytST two-component regulon reveals its contribution to oxidative stress tolerance},
  author={Sang-Joon Kenny Ahn and Ming-Da Qu and Elisha Roberts and Robert A Burne and Kelly C Rice},
  booktitle={BMC Microbiology},
  year={2012}
}
The S. mutans LrgA/B holin-like proteins have been shown to affect biofilm formation and oxidative stress tolerance, and are regulated by oxygenation, glucose levels, and by the LytST two-component system. In this study, we sought to determine if LytST was involved in regulating lrgAB expression in response to glucose and oxygenation in S. mutans. Real-time PCR revealed that growth phase-dependent regulation of lrgAB expression in response to glucose metabolism is mediated by LytST under low… CONTINUE READING

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