Identification of the Saccharomyces cerevisiae genes STB1–STB5 encoding Sin3p binding proteins

@article{Kasten1997IdentificationOT,
  title={Identification of the Saccharomyces cerevisiae genes STB1–STB5 encoding Sin3p binding proteins},
  author={Margaret M. Kasten and David J Stillman},
  journal={Molecular and General Genetics MGG},
  year={1997},
  volume={256},
  pages={376-386}
}
The yeast SIN3 gene functions as a transcriptional repressor, despite the fact that Sin3p does not bind DNA directly. We have conducted a two-hybrid screen to look for proteins that interact with Sin3p, using the PAH2 domain of Sin3p as bait. Five new genes, STB1–STB5 were identified, as well as the STB6 gene, which is similar to STB2. STB1, STB2, STB3, and STB6 are novel genes, and STB4 and STB5 encode C6 zinc cluster DNA-binding proteins. None of these genes is essential for viability, and… CONTINUE READING

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