Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis.

@article{Lee2003IdentificationOT,
  title={Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis.},
  author={Jong-Min Lee and Marcus J. Calkins and Kaimin Chan and Yuet Wai Kan and Jeffrey A. Johnson},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 14},
  pages={
          12029-38
        }
}
The antioxidant responsive element (ARE) mediates transcriptional regulation of phase II detoxification enzymes and antioxidant proteins such as NAD(P)H:quinone oxidoreductase (NQO1), glutathione S-transferases, and glutamate-cysteine ligase. In this study, we demonstrate that NF-E2-related factor-2 (Nrf2) plays a major role in transcriptional activation of ARE-driven genes and identify Nrf2-dependent genes by oligonucleotide microarray analysis using primary cortical astrocytes from Nrf2… CONTINUE READING
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