Identification of the Long-Sought Leptin in Chicken and Duck: Expression Pattern of the Highly GC-Rich Avian leptin Fits an Autocrine/Paracrine Rather Than Endocrine Function.

@article{Seroussi2016IdentificationOT,
  title={Identification of the Long-Sought Leptin in Chicken and Duck: Expression Pattern of the Highly GC-Rich Avian leptin Fits an Autocrine/Paracrine Rather Than Endocrine Function.},
  author={Eyal Seroussi and Yuval Cinnamon and Sara Yosefi and Olga Genin and Julia G. Smith and Nima Rafati and Susanne Bornel{\"o}v and Leif Andersson and Miriam Friedman-Einat},
  journal={Endocrinology},
  year={2016},
  volume={157 2},
  pages={
          737-51
        }
}
More than 20 years after characterization of the key regulator of mammalian energy balance, leptin, we identified the leptin (LEP) genes of chicken (Gallus gallus) and duck (Anas platyrhynchos). The extreme guanine-cytosine content (∼70%), the location in a genomic region with low-complexity repetitive and palindromic sequence elements, the relatively low sequence conservation, and low level of expression have hampered the identification of these genes until now. In vitro-expressed chicken and… Expand
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References

SHOWING 1-10 OF 79 REFERENCES
Discovery of a novel functional leptin protein (LEP) in zebra finches: evidence for the existence of an authentic avian leptin gene predominantly expressed in the brain and pituitary.
TLDR
The identified and characterized a LEP gene (zebra finch LEP [zbLEP]) encoding a 172-amino acid precursor in zebra finches, and synteny analysis proved that zbLEP is orthologous to mammalian LEP. Expand
Identification of a non-mammalian leptin-like gene: characterization and expression in the tiger salamander (Ambystoma tigrinum).
TLDR
The characterization of a salamander leptin-like gene provides a basis for understanding how the structure and functions of leptin have altered during the evolution of tetrapod vertebrates. Expand
Molecular cloning and properties of the chicken leptin-receptor (CLEPR) gene
TLDR
The cloning of the full-length chicken leptin receptor (CLEPR) cDNA is reported, which is the first non-mammalian cloning of a LEPR gene, and shows tight conservation of most previously characterized LEPR motifs and essential tyrosine residues. Expand
Leptin (ob gene) of the South African clawed frog Xenopus laevis.
  • E. Crespi, R. Denver
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006
TLDR
It is shown that recombinant frog leptin (rxLeptin) is a potent anorexigen in frogs, as it is in mammals, but this response does not develop until midprometamorphosis, and there is evidence that leptin can influence limb growth and differentiation during early development. Expand
Leptin and leptin receptor genes in Atlantic salmon: Cloning, phylogeny, tissue distribution and expression correlated to long-term feeding status.
TLDR
It is supported that sLepA1 is involved in signaling the energy status in fat-depositing tissues in line with the mammalian model, whereas sL LepA2 may possibly play important roles in the digestive tract and liver. Expand
Evolution of Leptin Structure and Function
TLDR
Vertebrate leptins show large divergence in their primary amino acid sequence, but may have similar potencies when tested in vitro on heterologous leptin receptors (LepRs), suggesting that its role in energy balance is ancient and has been evolutionarily conserved. Expand
Discovery and characterization of the first genuine avian leptin gene in the rock dove (Columba livia).
TLDR
Providing tools to study energy-balance control at an evolutionary perspective, the original demonstration of leptin signaling in dove predicts a more ancient role of leptin in growth and reproduction in birds, rather than appetite control. Expand
Molecular cloning and tissue distribution of a short form chicken leptin receptor mRNA.
TLDR
Structural analysis of intron 19 of the chLEPR andComparative sequence analysis identified two regions that are highly conserved between the chicken and mammals, indicating their possible importance as intronic elements in the regulation of alternative splicing of the LEPR in vertebrates. Expand
Leptin in teleostean fish, towards the origins of leptin physiology
TLDR
It is demonstrated that the power of a comparative approach leads to new insights on the origins of leptin physiology, as well as new and original insights are obtained because of the unique phylogenetic position of teleostean fish as the earliest vertebrates and because of their ectothermy. Expand
Cloning the chicken leptin gene.
TLDR
This is the first report showing that leptin gene expression in chicken is not exclusively localized in adipose tissue but is also expressed in liver, and the expression of leptin in liver may be associated with a key role of this organ in avian species in controlling lipogenesis. Expand
...
1
2
3
4
5
...