Identification of the Long-Sought Leptin in Chicken and Duck: Expression Pattern of the Highly GC-Rich Avian leptin Fits an Autocrine/Paracrine Rather Than Endocrine Function.

@article{Seroussi2016IdentificationOT,
  title={Identification of the Long-Sought Leptin in Chicken and Duck: Expression Pattern of the Highly GC-Rich Avian leptin Fits an Autocrine/Paracrine Rather Than Endocrine Function.},
  author={Eyal Seroussi and Yuval Cinnamon and Sara Yosefi and Olga Genin and Julia Gage Smith and Nima Rafati and Susanne Bornel{\"o}v and Leif Andersson and Miriam Friedman-Einat},
  journal={Endocrinology},
  year={2016},
  volume={157 2},
  pages={
          737-51
        }
}
More than 20 years after characterization of the key regulator of mammalian energy balance, leptin, we identified the leptin (LEP) genes of chicken (Gallus gallus) and duck (Anas platyrhynchos). The extreme guanine-cytosine content (∼70%), the location in a genomic region with low-complexity repetitive and palindromic sequence elements, the relatively low sequence conservation, and low level of expression have hampered the identification of these genes until now. In vitro-expressed chicken and… CONTINUE READING

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