Identification of the Lantibiotic Nisin Q, a New Natural Nisin Variant Produced by Lactococcus lactis 61-14 Isolated from a River in Japan

@article{Zendo2003IdentificationOT,
  title={Identification of the Lantibiotic Nisin Q, a New Natural Nisin Variant Produced by Lactococcus lactis 61-14 Isolated from a River in Japan},
  author={Takeshi Zendo and Masanori Fukao and Kyoko Ueda and Tomoko Higuchi and Jiro Nakayama and Kenji Sonomoto},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2003},
  volume={67},
  pages={1616 - 1619}
}
Lactococcus lactis 61-14 isolated from river water produced a bacteriocin active against a wide range of Gram-positive bacteria. N-terminal amino acid sequencing, mass spectral analysis of the purified bacteriocin, and genetic analysis using nisin-specific primers showed that the bacteriocin was a new natural nisin variant, termed nisin Q. Nisin Q and nisin A differ in four amino acids in the mature peptide and two in the leader sequence. 
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167 Citations
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167 Citations

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It is determined that while active Nisin Z, F, Q, U and Q can be produced against this genetic background, active forms of Nisin U and U2 are not generated.

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This is the first report both of characterization of a bacteriocin by S. uberis, as well as of a member of the nisin family of peptides in a species other than L. lactis.

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Structural Analysis and Characterization of Lacticin Q, a Novel Bacteriocin Belonging to a New Family of Unmodified Bacteriocins of Gram-Positive Bacteria

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Identification and Characterization of Lactocyclicin Q, a Novel Cyclic Bacteriocin Produced by Lactococcus sp. Strain QU 12

This is the first report of a cyclic bacteriocin purified from a strain belonging to the genus Lactococcus, and the sequence of the gene encoding the prepeptide lactocyclicin Q was obtained.

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