Identification of the INO1 gene of Mycobacterium tuberculosis H37Rv reveals a novel class of inositol-1-phosphate synthase enzyme.

@article{Bachhawat1999IdentificationOT,
  title={Identification of the INO1 gene of Mycobacterium tuberculosis H37Rv reveals a novel class of inositol-1-phosphate synthase enzyme.},
  author={Nandita Bachhawat and Shekhar C. Mande},
  journal={Journal of molecular biology},
  year={1999},
  volume={291 3},
  pages={531-6}
}
1L-myo-inositol (inositol) is vital for the biogenesis of mycothiol, phosphatidylinositol and glycosylphosphatidylinositol anchors linked to complex carbohydrates in Mycobacterium tuberculosis. All these cellular components are thought to play important roles in host-pathogen interactions and in the survival of the pathogen within the host. However, the inositol biosynthetic pathway in M. tuberculosis is not known. To delineate the pathways for inositol formation, we employed a unique… CONTINUE READING

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1L-myo-inositol-1-phosphate synthase.

Biochimica et biophysica acta • 1997
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