Identification of the IFITM3 gene as an inhibitor of hepatitis C viral translation in a stable STAT1 cell line.

@article{Yao2011IdentificationOT,
  title={Identification of the IFITM3 gene as an inhibitor of hepatitis C viral translation in a stable STAT1 cell line.},
  author={Luyu Yao and H Dong and H Zhu and David Nelson and C Liu and Lara Lambiase and X Li},
  journal={Journal of viral hepatitis},
  year={2011},
  volume={18 10},
  pages={e523-9}
}
To investigate the functions of signal transducers and activators of transcription 1 (STAT1)-induced anti-hepatitis C viral (HCV) effects, a stable Huh7.5 cell line (Huh7.5-STAT1ER) was established that constitutively expresses a fusion protein (STAT1ER) of STAT1 and the mouse oestrogen receptor (ER), which forms STAT1ER homodimers after 4-hydroxytamoxifen (4-HT) treatment. This inducible and cytokine/receptor-independent STAT1 activation system allowed us to investigate the anti-HCV effects of… CONTINUE READING