Identification of the IFITM family as a new molecular marker in human colorectal tumors.

@article{Andreu2006IdentificationOT,
  title={Identification of the IFITM family as a new molecular marker in human colorectal tumors.},
  author={Pauline Andreu and Sabine Colnot and C{\'e}cile Godard and Pierre Laurent-Puig and Dominique Lamarque and Axel Kahn and C. Perret and B{\'e}atrice Romagnolo},
  journal={Cancer research},
  year={2006},
  volume={66 4},
  pages={1949-55}
}
We analyzed the expression profiles of intestinal adenomas from a new murine familial adenomatous polyposis model (Apc(delta14/+)) using suppression subtractive hybridization to identify novel diagnostic markers of colorectal carcinogenesis. We identified 18 candidate genes having increased expression levels in the adenoma. Subsequent Northern blotting, real-time reverse transcription-PCR, and in situ hybridization analysis confirmed their induction in beta-catenin-activated epithelial cells of… CONTINUE READING