Identification of the HIV-1 Vif and Human APOBEC3G Protein Interface.

@article{Letko2015IdentificationOT,
  title={Identification of the HIV-1 Vif and Human APOBEC3G Protein Interface.},
  author={Michael Letko and Thijs Booiman and Neeltje A Kootstra and Viviana A Simon and Marcel Ooms},
  journal={Cell reports},
  year={2015},
  volume={13 9},
  pages={1789-99}
}
Human cells express natural antiviral proteins, such as APOBEC3G (A3G), that potently restrict HIV replication. As a counter-defense, HIV encodes the accessory protein Vif, which binds A3G and mediates its proteasomal degradation. Our structural knowledge on how Vif and A3G interact is limited, because a co-structure is not available. We identified specific points of contact between Vif and A3G by using functional assays with full-length A3G, patient-derived Vif variants, and HIV forced… CONTINUE READING
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