Identification of the Fc gamma receptor class I binding site in human IgG through the use of recombinant IgG1/IgG2 hybrid and point-mutated antibodies.

@article{Chappel1991IdentificationOT,
  title={Identification of the Fc gamma receptor class I binding site in human IgG through the use of recombinant IgG1/IgG2 hybrid and point-mutated antibodies.},
  author={M S Chappel and David E. Isenman and Margaret F Everett and Yuan Yuan Xu and K J. Dorrington and Michel H. Klein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 20},
  pages={9036-40}
}
To characterize the region on human IgG1 responsible for its high-affinity interaction with the human Fc gamma receptor class I (Fc gamma RI), we have analyzed the binding properties of a series of genetically engineered chimeric antidinitrophenyl antibodies with identical murine antibody combining sites and hybrid IgG1/IgG2 human constant (C) regions. In… CONTINUE READING