Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury

Abstract

Here we defined the main viral determinant of Ebola virus pathogenicity; synthesis of the virion glycoprotein (GP) of Ebola virus Zaire induced cytotoxic effects in human endothelial cells in vitro and in vivo. This effect mapped to a serine–threonine-rich, mucin-like domain of this type I transmembrane glycoprotein, one of seven gene products of the virus… (More)
DOI: 10.1038/78654

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@article{Yang2000IdentificationOT, title={Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury}, author={Zhi-Yong Yang and Henricus Johannes Duckers and Nancy J. Sullivan and Anthony Sanchez and Elizabeth G. Nabel and Gary J. Nabel}, journal={Nature Medicine}, year={2000}, volume={6}, pages={886-889} }