Identification of the DNA damage-responsive element of RNR2 and evidence that four distinct cellular factors bind it.

@article{Elledge1989IdentificationOT,
  title={Identification of the DNA damage-responsive element of RNR2 and evidence that four distinct cellular factors bind it.},
  author={Stephen J Elledge and Ronald W. Davis},
  journal={Molecular and cellular biology},
  year={1989},
  volume={9 12},
  pages={5373-86}
}
The RNR2 gene encodes the small subunit of ribonucleotide reductase, the enzyme that catalyzes the first step in the pathway for the production of the deoxyribonucleotides needed for DNA synthesis. Transcription of this gene is induced approximately 20-fold in response to environmental stimuli that damage DNA or block DNA replication. Deletion and subcloning analysis identified two, and possibly three, upstream activating sequences (UAS) and one repressing (URS) element in the RNR2 regulatory… CONTINUE READING