Identification of the C-terminal activator domain in yeast heat shock factor: independent control of transient and sustained transcriptional activity.

@article{Chen1993IdentificationOT,
  title={Identification of the C-terminal activator domain in yeast heat shock factor: independent control of transient and sustained transcriptional activity.},
  author={Ying-yu Chen and Nickolai A. Barlev and Ole Westergaard and Bodil K. Jakobsen},
  journal={The EMBO journal},
  year={1993},
  volume={12 13},
  pages={5007-18}
}
In yeast, heat shock factor (HSF) is a trimer that binds DNA constitutively but only supports high levels of transcription upon heat shock. The C-terminal regions of HSF from Saccharomyces cerevisiae and Kluyveromyces lactis are unconserved yet both contain strong transactivators which are correctly regulated when substituted for each other. We have performed high resolution mapping of these activator domains which shows that in K.lactis HSF (KlHSF) activity can be located to a confined short… CONTINUE READING

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