Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.

@article{Patteson2018IdentificationOT,
  title={Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.},
  author={Jon B Patteson and Wenlong Cai and Rachel A. Johnson and Kevin C Santa Maria and Bo Li},
  journal={Biochemistry},
  year={2018},
  volume={57 1},
  pages={61-65}
}
Diketopiperazines (DKPs) make up a large group of natural products with diverse structures and biological activities. Bicyclomycin is a broad-spectrum DKP antibiotic with unique structure and function: it contains a highly oxidized bicyclic [4.2.2] ring and is the only known selective inhibitor of the bacterial transcription termination factor, Rho. Here… CONTINUE READING