Identification of the B-cell tumor-specific molecular fingerprint using non-radiolabelled PCR consensus primers.

@article{Bendandi2001IdentificationOT,
  title={Identification of the B-cell tumor-specific molecular fingerprint using non-radiolabelled PCR consensus primers.},
  author={Maurizio Bendandi and Rossella Tonelli and Roberto Maffei and Sara Botti and Christina E. Turi and Roberta Sartini and Susana Inog{\'e}s and Michaela Calvillo and Pier Luigi Zinzani and Annalisa Pession and Stefano A Pileri and Giancarlo Paolucci},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2001},
  volume={12 10},
  pages={1479-84}
}
BACKGROUND The complementarity determining region 3 (CDR3) of the immunoglobulin (Ig) heavy chain variable region (VH) is the most reliable molecular fingerprint for most if not all human B cells. The nucleotide sequence encoding for any B-cell tumor-specific VH CDR3 is currently identified by PCR sequencing based on procedures involving the usage of either radioactive materials, patient/family-specific primers, or bacterial cloning. PATIENTS AND METHODS In six consecutive patients with… CONTINUE READING

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