Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

@article{Reyes1992IdentificationOT,
  title={Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor},
  author={H. Reyes and S. Reisz-Porszasz and O. Hankinson},
  journal={Science},
  year={1992},
  volume={256},
  pages={1193 - 1195}
}
  • H. Reyes, S. Reisz-Porszasz, O. Hankinson
  • Published 1992
  • Biology, Medicine
  • Science
    • The Ah (dioxin) receptor binds a number of widely disseminated environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons, and mediates their carcinogenic effects. The ligand-bound receptor activates Cyp1a1 gene transcription through interaction with specific DNA sequences, termed xenobiotic responsive elements (XREs). The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function. Arnt is now shown to be a… CONTINUE READING
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