Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

@article{Reyes1992IdentificationOT,
  title={Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor},
  author={H. Reyes and S. Reisz-Porszasz and O. Hankinson},
  journal={Science},
  year={1992},
  volume={256},
  pages={1193 - 1195}
}
  • H. Reyes, S. Reisz-Porszasz, O. Hankinson
  • Published 1992
  • Biology, Medicine
  • Science
  • The Ah (dioxin) receptor binds a number of widely disseminated environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons, and mediates their carcinogenic effects. The ligand-bound receptor activates Cyp1a1 gene transcription through interaction with specific DNA sequences, termed xenobiotic responsive elements (XREs). The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function. Arnt is now shown to be a… CONTINUE READING
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    References

    SHOWING 1-10 OF 43 REFERENCES
    Cloning of a factor required for activity of the Ah (dioxin) receptor.
    • 922
    Aryl hydrocarbon (Ah) receptor DNA-binding activity. Sequence specificity and Zn2+ requirement.
    • 29
    Specific protein-DNA interactions at a xenobiotic-responsive element: copurification of dioxin receptor and DNA-binding activity.
    • 65
    • PDF
    Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer.
    • 191
    • PDF