Identification of the Abl- and rasGAP-Associated 62 kDa Protein as a Docking Protein, Dok

  title={Identification of the Abl- and rasGAP-Associated 62 kDa Protein as a Docking Protein, Dok},
  author={Y. Yamanashi and D. Baltimore},
  • Y. Yamanashi, D. Baltimore
  • Published 1997
  • Biology, Medicine
  • Cell
  • A 62 kDa protein is highly phosphorylated in many cells containing activated tyrosine kinases. This protein, characterized mainly by its avid association with rasGAP, has proved elusive. Anti-phosphotyrosine antibody was used to purify p62. From peptide sequence, molecular cloning revealed a cDNA encoding a novel protein, p62dok, with little homology to others but with a prominent set of tyrosines and nearby sequences suggestive of SH2 binding sites. In cells, v-Abl tyrosine kinase binds and… CONTINUE READING
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