Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

@article{Baekkeskov1990IdentificationOT,
  title={Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase},
  author={Steinunn Baekkeskov and Hj Aanstoot and Stephan Christgai and Annette Reetz and Michele Solimena and Marilia I Cascalho and Franco Folli and Hanne Richter-Olesen and P Camilli},
  journal={Nature},
  year={1990},
  volume={347},
  pages={151-156}
}
The pancreatic islet β-cell autoantigen of relative molecular mass 64,000 (64K), which is a major target of autoantibodies associated with the development of insulin-dependent diabetes mel-litus (IDDM) has been identified as glutamic acid decarboxylase, the biosynthesizing enzyme of the inhibitory neurotransmitter GABA (γ-aminobutyric acid). Pancreatic β cells and a subpopulation of central nervous system neurons express high levels of this enzyme. Autoantibodies against glutamic acid… CONTINUE READING