Identification of the 16S rRNA m5C967 methyltransferase from Escherichia coli.

@article{Gu1999IdentificationOT,
  title={Identification of the 16S rRNA m5C967 methyltransferase from Escherichia coli.},
  author={Xiang-rong Gu and Claes Gustafsson and Jakang Ku and Minmin Yu and Daniel V Santi},
  journal={Biochemistry},
  year={1999},
  volume={38 13},
  pages={4053-7}
}
The fmu gene product has been proposed to be an RNA methyltransferase [Koonin, E. V. (1994) Nucleic Acids Res. 22, 2476-2478]. Fmu has been cloned and expressed, and the encoded 47 kDa protein has been purified and characterized. The enzyme catalyzed specific methylation of C967 of unmodified 16S rRNA transcripts. A 16mer stem-loop structure containing C967 (nt 960-975) was also a good substrate for the enzyme in vitro. Methylation of C967 was confirmed by several methods including analysis of… CONTINUE READING
Highly Cited
This paper has 69 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

69 Citations

01020'01'04'08'12'16
Citations per Year
Semantic Scholar estimates that this publication has 69 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…