Identification of tetrabromobisphenol A diallyl ether as an emerging neurotoxicant in environmental samples by bioassay-directed fractionation and HPLC-APCI-MS/MS.

@article{Qu2011IdentificationOT,
  title={Identification of tetrabromobisphenol A diallyl ether as an emerging neurotoxicant in environmental samples by bioassay-directed fractionation and HPLC-APCI-MS/MS.},
  author={Guangbo Qu and Jianbo Shi and Thanh Wang and Jianjie Fu and Zhuona Li and Pu Wang and T. Du A. W. Ruan and Guibin Jiang},
  journal={Environmental science & technology},
  year={2011},
  volume={45 11},
  pages={5009-16}
}
Brominated flame retardants (BFRs) have been widely used as additives in products to reduce their flammability. Recent findings suggested that some BFRs exhibit neurotoxicity and thus might pose a threat to human health. In this work, a neurotoxicity assay-directed analysis was developed, combining sample cleanup, fractionation, chemical identification, and bioassay. Viability of primary cultured cerebellar granule neurons (CGNs) was used to evaluate the neurotoxicity of extracts or separated… CONTINUE READING

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