Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche

  title={Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche},
  author={Yanming Bi and Driss Ehirchiou and Tina M. Kilts and Colette A Inkson and Mildred C. Embree and Wataru Sonoyama and Li Li and Arabella I Leet and B Seo and Li Zhang and Songtao Shi and Marian Francis Young},
  journal={Nature Medicine},
The repair of injured tendons remains a great challenge, largely owing to a lack of in-depth characterization of tendon cells and their precursors. We show that human and mouse tendons harbor a unique cell population, termed tendon stem/progenitor cells (TSPCs), that has universal stem cell characteristics such as clonogenicity, multipotency and self-renewal capacity. The isolated TSPCs could regenerate tendon-like tissues after extended expansion in vitro and transplantation in vivo. Moreover… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 60 references

an in vitro cell differentiation study

de Mos, M. et al. Intrinsic differentiation potential of adol tissue
BMC Musculoskelet. Disord. 8, 16 • 2007

Biology of tendon injury: healing, modeling and remodeling.

Journal of musculoskeletal & neuronal interactions • 2006

Epidermal stem cells of the skin.

Annual review of cell and developmental biology • 2006

healing, modeling and remodeling

P. Sharma, Maffulli, N. Biology of tendon injury
J. Musculoskelet. Neuronal Interact. 6, 181–190 • 2006

Defective osteogenesis of the stromal stem cells predisposes CD18-null mice to osteoporosis.

Proceedings of the National Academy of Sciences of the United States of America • 2005

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