Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.

@article{Tomsig2003IdentificationOT,
  title={Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.},
  author={Jose Luis Tomsig and Sandra L Snyder and Carl E. Creutz},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 12},
  pages={10048-54}
}
We provide evidence that copines, members of a ubiquitous family of calcium-dependent, membrane-binding proteins, may represent a universal transduction pathway for calcium signaling because we find copines are capable of interacting with a wide variety of "target" proteins including MEK1, protein phosphatase 5, and the CDC42-regulated kinase, that are themselves components of intracellular signaling pathways. The copine target proteins were identified by yeast two-hybrid screening and the… CONTINUE READING

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