Identification of targetable FGFR gene fusions in diverse cancers.

  title={Identification of targetable FGFR gene fusions in diverse cancers.},
  author={Yi-mi Wu and Fengyun Su and Shanker Kalyana-Sundaram and Nickolay A. Khazanov and Bushra Ateeq and Xuhong Cao and Robert J. Lonigro and Pankaj Vats and Rui Wang and Su-Fang Lin and A Cheng and Lakshmi Priya Kunju and Javed Ather Siddiqui and Scott Arthur Tomlins and Peter Wyngaard and Seth E Sadis and Sameek Roychowdhury and Maha H A Hussain and Felix Feng and Mark M. Zalupski and Moshe Talpaz and Kenneth J. Pienta and Daniel R. Rhodes and D. R. T. Robinson and Arul M. Chinnaiyan},
  journal={Cancer discovery},
  volume={3 6},
Through a prospective clinical sequencing program for advanced cancers, four index cases were identified which harbor gene rearrangements of FGFR2, including patients with cholangiocarcinoma, breast cancer, and prostate cancer. After extending our assessment of FGFR rearrangements across multiple tumor cohorts, we identified additional FGFR fusions with intact kinase domains in lung squamous cell cancer, bladder cancer, thyroid cancer, oral cancer, glioblastoma, and head and neck squamous cell… CONTINUE READING
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