Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.

@article{Barber2002IdentificationOT,
  title={Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.},
  author={Thomas D. Barber and Melisa Carey Barber and Oana A. Tomescu and F. G. Barr and Steve M. Ruben and Thomas B Friedman},
  journal={Genomics},
  year={2002},
  volume={79 3},
  pages={
          278-84
        }
}
PAX3 is a transcription factor important for neural, muscle, and facial development in vertebrates. To identify genes regulated by PAX3, we used a cyclic amplification and selection of targets (CASTing) strategy to isolate cis-regulatory elements bound by PAX3. CASTing libraries were constructed with mouse DNA fragments bound by mouse PAX3, and human genomic DNA fragments bound by human PAX3 and the fusion protein PAX3-FKHR. Approximately 1000 clones were sequenced from each of these three… CONTINUE READING
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