Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides

@inproceedings{Rebollo2014IdentificationOT,
  title={Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides},
  author={Inmaculada Rentero Rebollo and Michal Sabisz and Vanessa Baeriswyl and Christian Heinis},
  booktitle={Nucleic acids research},
  year={2014}
}
High-throughput sequencing was previously applied to phage-selected peptides in order to gain insight into the abundance and diversity of isolated peptides. Herein we developed a procedure to efficiently compare the sequences of large numbers of phage-selected peptides for the purpose of identifying target-binding peptide motifs. We applied the procedure to analyze bicyclic peptides isolated against five different protein targets: sortase A, urokinase-type plasminogen activator, coagulation… CONTINUE READING