Identification of synthetic lethality of PLK1 inhibition and microtubule-destabilizing drugs

@article{Hugle2015IdentificationOS,
  title={Identification of synthetic lethality of PLK1 inhibition and microtubule-destabilizing drugs},
  author={Manuela Hugle and Kristina Belz and Simone Fulda},
  journal={Cell Death and Differentiation},
  year={2015},
  volume={22},
  pages={1946-1956}
}
Polo-like kinase 1 (PLK1) is frequently overexpressed in cancer, which correlates with poor prognosis. Therefore, we investigated PLK1 as therapeutic target using rhabdomyosarcoma (RMS) as a model. Here, we identify a novel synthetic lethal interaction of PLK1 inhibitors and microtubule-destabilizing drugs in preclinical RMS models and elucidate the underlying molecular mechanisms of this synergism. PLK1 inhibitors (i.e., BI 2536 and BI 6727) synergistically induce apoptosis together with… CONTINUE READING
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