Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells

@article{Tucker2003IdentificationOS,
  title={Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells},
  author={Ward C. Tucker and J Michael Edwardson and Jihong Bai and Hyun-Jung Kim and Thomas F J Martin and Edwin R Chapman},
  journal={The Journal of Cell Biology},
  year={2003},
  volume={162},
  pages={199 - 209}
}
The synaptotagmins (syts) are a family of membrane proteins proposed to regulate membrane traffic in neuronal and nonneuronal cells. In neurons, the Ca2+-sensing ability of syt I is critical for fusion of docked synaptic vesicles with the plasma membrane in response to stimulation. Several putative Ca2+-syt effectors have been identified, but in most cases the functional significance of these interactions remains unknown. Here, we have used recombinant C2 domains derived from the cytoplasmic… CONTINUE READING
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