Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans

@article{Boss2009IdentificationOS,
  title={Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans},
  author={Yohan Boss{\'e} and François Bacot and Alexandre Montpetit and Johan Rung and H T Qu and James C. Engert and Constantin Polychronakos and Thomas J. Hudson and Philippe Froguel and Robert Sladek and Martin Desrosiers},
  journal={Human Genetics},
  year={2009},
  volume={125},
  pages={305-318}
}
The success of genome-wide association studies (GWAS) to identify risk loci of complex diseases is now well-established. One persistent major hurdle is the cost of those studies, which make them beyond the reach of most research groups. Performing GWAS on pools of DNA samples may be an effective strategy to reduce the costs of these studies. In this study, we performed pooling-based GWAS with more than 550,000 SNPs in two case-control cohorts consisting of patients with Type II diabetes (T2DM… CONTINUE READING

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