Identification of subtilase cytotoxin (SubAB) receptors whose signaling, in association with SubAB-induced BiP cleavage, is responsible for apoptosis in HeLa cells.

@article{Yahiro2011IdentificationOS,
  title={Identification of subtilase cytotoxin (SubAB) receptors whose signaling, in association with SubAB-induced BiP cleavage, is responsible for apoptosis in HeLa cells.},
  author={Kinnosuke Yahiro and Mamoru Satoh and Naoko Morinaga and Hiroyasu Tsutsuki and Kohei Ogura and Sayaka Nagasawa and Fumio Nomura and Joel Moss and M. T. Noda},
  journal={Infection and immunity},
  year={2011},
  volume={79 2},
  pages={617-27}
}
Subtilase cytotoxin (SubAB), which is produced by certain strains of Shiga-toxigenic Escherichia coli (STEC), causes the 78-kDa glucose-regulated protein (GRP78/BiP) cleavage, followed by induction of endoplasmic reticulum (ER) stress, leading to caspase-dependent apoptosis via mitochondrial membrane damage by Bax/Bak activation. The purpose of the present study was to identify SubAB receptors responsible for HeLa cell death. Four proteins, NG2, α2β1 integrin (ITG), L1 cell adhesion molecule… CONTINUE READING

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