Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities.

@article{Matthews2009IdentificationOS,
  title={Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities.},
  author={Edwin J Matthews and Carling J Ursem and Naomi L Kruhlak and R Daniel Benz and David Aragon{\'e}s Sabat{\'e} and Chihae Yang and Gilles Klopman and Joseph F Contrera},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2009},
  volume={54 1},
  pages={23-42}
}
This report describes the development of quantitative structure-activity relationship (QSAR) models for predicting rare drug-induced liver and urinary tract injury in humans based upon a database of post-marketing adverse effects (AEs) linked to approximately 1600 chemical structures. The models are based upon estimated population exposure using AE proportional reporting ratios. Models were constructed for 5 types of liver injury (liver enzyme disorders, cytotoxic injury, cholestasis and… CONTINUE READING

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