Identification of structurally diverse methanofuran coenzymes in methanococcales that are both N-formylated and N-acetylated.

@article{Allen2014IdentificationOS,
  title={Identification of structurally diverse methanofuran coenzymes in methanococcales that are both N-formylated and N-acetylated.},
  author={Kylie D. Allen and Robert H White},
  journal={Biochemistry},
  year={2014},
  volume={53 39},
  pages={
          6199-210
        }
}
Methanofuran (MF) is a coenzyme necessary for the first step of methanogenesis from CO2. The well-characterized MF core structure is 4-[N-(γ-l-glutamyl-γ-l-glutamyl)-p-(β-aminoethyl)phenoxymethyl]-2-(aminomethyl)furan (APMF-γ-Glu2). Three different MF structures that differ on the basis of the composition of their side chains have been determined previously. Here, we use liquid chromatography coupled with high-resolution mass spectrometry and a variety of biochemical methods to deduce the… Expand
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TLDR
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