Identification of structural elements of a scorpion alpha-neurotoxin important for receptor site recognition.

@article{Zilberberg1997IdentificationOS,
  title={Identification of structural elements of a scorpion alpha-neurotoxin important for receptor site recognition.},
  author={N. V. Zilberberg and Oren Froy and Erwann P. Loret and Sandrine Cest{\`e}le and Dorit Arad and Dalia Gordon and Michael Gurevitz},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 23},
  pages={14810-6}
}
alpha-Neurotoxins from scorpion venoms constitute the most studied group of modifiers of the voltage-sensitive sodium channels, and yet, their toxic site has not been characterized. We used an efficient bacterial expression system for modifying specific amino acid residues of the highly insecticidal alpha-neurotoxin LqhalphaIT from the scorpion Leiurus quinquestriatus hebraeus. Toxin variants modified at tight turns, the C-terminal region, and other structurally related regions were subjected… CONTINUE READING

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