Identification of staphylococcal nuclease domain-containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions.

@article{Blanco2011IdentificationOS,
  title={Identification of staphylococcal nuclease domain-containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions.},
  author={Mario Andres Blanco and Ma{\vs}a Ale{\vc}kovi{\'c} and Yuling Hua and Tuo Li and Yong Wei and Zhen Xu and Ileana M. Cristea and Yibin Kang},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 22},
  pages={19982-92}
}
Metastasis is the deadliest and most poorly understood feature of malignant diseases. Recent work has shown that Metadherin (MTDH) is overexpressed in over 40% of breast cancer patients and promotes metastasis and chemoresistance in experimental models of breast cancer progression. Here we applied mass spectrometry-based screen to identify staphylococcal nuclease domain-containing 1 (SND1) as a candidate MTDH-interacting protein. After confirming the interaction between SND1 and MTDH, we tested… CONTINUE READING

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