Identification of stable cytotoxic factors in the gas phase extract of cigarette smoke and pharmacological characterization of their cytotoxicity.

@article{Noya2013IdentificationOS,
  title={Identification of stable cytotoxic factors in the gas phase extract of cigarette smoke and pharmacological characterization of their cytotoxicity.},
  author={Y. Noya and K. Seki and H. Asano and Y. Mai and T. Horinouchi and T. Higashi and K. Terada and Chizuru Hatate and A. Hoshi and Prabha Nepal and Mika Horiguchi and Y. Kuge and S. Miwa},
  journal={Toxicology},
  year={2013},
  volume={314 1},
  pages={
          1-10
        }
}
Smoking is a major risk factor for atherosclerotic vascular diseases, but the mechanism for its genesis is unknown. We have recently shown that the gas phase of cigarette smoke (nicotine- and tar-free cigarette smoke extract; CSE) likely to reach the systemic circulation contains stable substances which cause cytotoxicity like plasma membrane damage and cell death in cultured cells, and also that the plasma membrane damage is caused through sequential activation of protein kinase C (PKC) and… Expand
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