Identification of splenic reservoir monocytes and their deployment to inflammatory sites.

@article{Swirski2009IdentificationOS,
  title={Identification of splenic reservoir monocytes and their deployment to inflammatory sites.},
  author={Filip K Swirski and Matthias Nahrendorf and Martin Etzrodt and Moritz Georg Wildgruber and Virna Cortez-Retamozo and Peter Panizzi and Jose-Luiz Figueiredo and Rainer H Kohler and Aleksey Chudnovskiy and Peter Waterman and Elena Aikawa and Thorsten R Mempel and Peter Libby and Ralph Weissleder and Mikael J Pittet},
  journal={Science},
  year={2009},
  volume={325 5940},
  pages={
          612-6
        }
}
A current paradigm states that monocytes circulate freely and patrol blood vessels but differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry. Here we show that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation. The reservoir monocytes assemble in clusters in the cords of the subcapsular red pulp and are distinct from macrophages and DCs. In response to ischemic myocardial injury, splenic monocytes increase… CONTINUE READING

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J. Gervain, F. Macagno, S. Cogoi, M. Peña, J. Mehler
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