Identification of specific nucleotide sequences and structural elements required for intronic U14 snoRNA processing.

@article{Xia1997IdentificationOS,
  title={Identification of specific nucleotide sequences and structural elements required for intronic U14 snoRNA processing.},
  author={Ling Xia and Nicholas James Watkins and E. S. Maxwell},
  journal={RNA},
  year={1997},
  volume={3 1},
  pages={17-26}
}
Vertebrate U14 snoRNAs are encoded within hsc70 pre-mRNA introns and U14 biosynthesis occurs via an intron-processing pathway. We have shown previously that essential processing signals are located in the termini of the mature U14 molecule and replacement of included boxes C or D with oligo C disrupts snoRNA synthesis. The experiments detailed here now define the specific nucleotide sequences and structures of the U14 termini that are essential for intronic snoRNA processing. Mutagenesis… CONTINUE READING
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