Identification of specific autoantigens in Sjögren's syndrome by SEREX.

  title={Identification of specific autoantigens in Sj{\"o}gren's syndrome by SEREX.},
  author={Kazuo Uchida and Yoichi Akita and Keitaro Matsuo and Shigeyoshi Fujiwara and Atsuko Nakagawa and Yoshiaki Kazaoka and Hiroshi Hachiya and Yoshiyuki Naganawa and Ichiro Oh-iwa and Kiyoshi Ohura and Shinsuke Saga and Tatsushi Kawai and Yoshinari Matsumoto and Kazuo Shimozato and Ken-ichi Kozaki},
  volume={116 1},
We carried out SEREX (serological analysis of antigens by recombinant cDNA expression cloning) using sera from patients with Sjögren's syndrome (SjS) and investigated the frequencies of autoantibodies against autoantigens identified by SEREX in the sera of healthy individuals (HI) and patients with SjS, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). IFI16 and two kelch-like proteins, KLHL12 and KLHL7, were found to be novel autoantigens in SjS by SEREX. A markedly high… CONTINUE READING


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